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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

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Author(s):
Miguel, Danilo Ciccone [1] ; Ferraz, Marcela Lencine [2] ; Alves, Rosana de Oliveira [2] ; Yokoyama-Yasunaka, Jenicer K. U. [1] ; Torrecilhas, Ana Claudia [1] ; Romanha, Alvaro Jose [2] ; Uliana, Silvia R. B. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, BR-05508000 Sao Paulo - Brazil
[2] Inst Pesquisas Rene Rachou Fiocruz, Lab Parasitol Celular & Mol, Belo Horizonte, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 105, n. 7, p. 945-948, NOV 2010.
Web of Science Citations: 6
Abstract

The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice. (AU)