LONG-TERM THERAPY WITH DEFLAZACORT DECREASES MYOCARDIAL FIBROSIS IN mdx MICE

Autor(es)

Marques, Maria Julia ^[1] ; Oggiam, Daniella Silva ^[1] ; Chagas Barbin, Isabel Cristina ^[1] ; Ferretti, Renato ^[1] ; Santo Neto, Humberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Anat, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MUSCLE & NERVE; v. 40, n. 3, p. 466-468, SEP 2009.
• Citações Web of Science: 14

Resumo

We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart. Muscle Nerve 40: 466-468, 2009 (AU)

• Processo FAPESP: 01/00570-4 - Distribuição do peptídeo relacionado ao gene da calcitonina e das células de Schwann terminais, na junção neuromuscular de animais distróficos da linhagem Mdx
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/15526-9 - Proteínas reguladoras do cálcio e proteção à mionecrose na distrofia muscular de Duchenne
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular