| Full text | |
| Author(s): |
Marques, Maria Julia
[1]
;
Oggiam, Daniella Silva
[1]
;
Chagas Barbin, Isabel Cristina
[1]
;
Ferretti, Renato
[1]
;
Santo Neto, Humberto
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Anat, Inst Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | MUSCLE & NERVE; v. 40, n. 3, p. 466-468, SEP 2009. |
| Web of Science Citations: | 14 |
| Abstract | |
We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart. Muscle Nerve 40: 466-468, 2009 (AU) | |