The Role of Prokineticins in the Pathogenesis of Hypogonadotropic Hypogonadism

Autor(es)

Abreu, Ana Paula ^{[1, 2]} ; Kaiser, Ursula B. ^{[1, 2]} ; Latronico, Ana Claudia ^[3]

Afiliação do(s) autor(es)

^[1] Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 - USA

^[2] Harvard Univ, Sch Med, Boston, MA - USA

^[3] Univ Sao Paulo, Lab Hormonios & Genet Mol, Disciplina Endocrinol & Metabol, Hosp Clin, Unidade Endocrinol Desenvolvimento, Fac Med, BR-05403900 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Neuroendocrinology; v. 91, n. 4, p. 283-290, 2010.
• Citações Web of Science: 14

Resumo

The prokineticin system comprises two multifunctional secreted proteins, prokineticin-1 (PROK1) and prokineticin-2 (PROK2), and their cognate G protein-coupled receptors. The prokineticins were originally identified as endogenous regulators of gastrointestinal motility. Currently, these bioactive peptides are involved in a wide spectrum of biological functions, including angiogenesis, neurogenesis, circadian rhythms, nociception, hematopoiesis and immune response. Mice homozygous for null mutations in Prokr2 or Prok2 recapitulate the human phenotype of Kallmann syndrome, exhibiting severe atrophy of the reproductive system and hypoplastic olfactory bulbs. Indeed, the evidence from several naturally inactivating mutations in the PROK2 and PROKR2 genes in patients with Kallmann syndrome and normosmic hypogonadotropic hypogonadism also indicate the essential role of PROK2 in olfactory bulb morphogenesis and GnRH secretion in humans. Copyright (c) 2010 S. Karger AG, Basel (AU)

• Processo FAPESP: 06/56753-3 - Pesquisa de mutações no gene do receptor da proquineticina 2 em pacientes com Síndrome de Kallmann
• Beneficiário: Ana Paula de Abreu e Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 05/04726-0 - Caracterização molecular das doenças endócrinas congênitas que afetam o crescimento e o desenvolvimento
• Beneficiário: Ana Claudia Latronico Xavier
• Modalidade de apoio: Auxílio à Pesquisa - Temático