| Texto completo | |
| Autor(es): |
Pompeia, Sabine
[1]
;
Grego, Bruno H. C.
[1]
;
Pradella-Hallinan, Marcia
[1]
;
Hachul, Helena
[1]
;
Tufik, Sergio
[1]
;
D'Almeida, Vania
[2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, BR-04024002 Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 33, n. 6, p. 933-938, AUG 31 2009. |
| Citações Web of Science: | 3 |
| Resumo | |
Purpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, could decrease homocysteine, and if changes were similar in both genders. Methods: This was a double-blind, cross-over design study Of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n = 21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of flunitrazepam was reached). Various biochemical parameters were analysed, such as plasma homocysteine, cysteine, folate, vitamins B6, B12, and sexual hormones. Results: Flunitrazepam reduced cortisol (p = 0.0011), cysteine (p = 0.014) and homocysteine (p = 0.028) concentrations, irrespective of gender. No correlations were found between cortisol and other biochemical markers (all r's<0.03). Concentration of cysteine and homocysteine were negatively correlated with plasma flunitrazepam concentration, suggesting that changes in these amino acids might be related to the metabolism of this benzodiazepine. Conclusion: Acute administration of flunitrazepam decreases plasma homocysteine and cysteine by mechanisms that seem unrelated to changes in cortisol. Given the importance of homocysteine as a market of life-threatening disorders, the mechanisms involved in the decrease of these amino acids are potential targets for clinical application. (C) 2009 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 03/00046-9 - Efeitos cognitivos atípicos do benzodiazepínico lorazepam |
| Beneficiário: | Sabine Pompéia |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 05/03552-8 - Efeitos do gênero, estresse psicológico e uso de benzodiazepínicos sobre as concentrações plasmáticas de homocisteína |
| Beneficiário: | Bruno Henrique Do Carmo Grego |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 98/14303-3 - Center for Sleep Studies |
| Beneficiário: | Sergio Tufik |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |