| Texto completo | |
| Autor(es): |
Vianna‚ D.M.L.
;
Graeff‚ F.G.
;
Landeira-Fernandez‚ J.
;
Brandão‚ M.L.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | LEARNING & MEMORY; v. 8, n. 3, p. 164-169, 2001. |
| Resumo | |
Previously-reported evidence showed that freezing to a context previously associated with footshock is impaired by lesion of the ventral periaqueductal gray (vPAG). It has also been shown that stepwise increase in the intensity of the electrical stimulation of the dorsal periaqueductal gray (dPAG) produces alertness, then freezing, and finally escape. These aversive responses are mimicked by microinjections of GABA receptor antagonists, such as bicuculline, or blockers of the glutamic acid decarboxylase (GAD), such as semicarbazide. into the dPAG. In this work, we examined whether the expression of these defensive responses could be the result of activation of ventral portion of the periaqueductal gray. Sham- or vPAG electrolytic-lesioned rats were implanted with an electrode in the dPAG for the determination of the thresholds of freezing and escape responses. The VPAG electrolytic lesions were behaviorally verified through a context-conditioned fear paradigm. Results indicated that lesion of the vPAG disrupted conditioned freezing response to contextual cues associated with footshocks but did not change the dPAG electrical stimulation for freezing and escape responses. In a second experiment, lesion of the vPAG also did not change the amount of freezing and escape behavior produced by microinjections of semicarbazide into the dPAG. These findings indicate that freezing and escape defensive responses induced by dPAG stimulation do not depend on the integrity of the vPAG. A discussion on different neural circuitries that might underlie different inhibitory and active defensive behavioral patterns that animals display during threatening situations is presented. (AU) | |
| Processo FAPESP: | 98/11187-2 - Neurobiologia do medo e da ansiedade |
| Beneficiário: | Marcus Lira Brandão |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |