Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis

Autor(es)

Mendonca, Jose Alexandre ^[1] ; Marques-Neto, Joao Francisco ^[2] ; Samara, Adil Muhib ^[2] ; Appenzeller, Simone ^[2]

Afiliação do(s) autor(es)

^[1] Pontifica Univ Campinas, Rheumatol Serv, Campinas, SP - Brazil

^[2] Univ Estadual Campinas UNICAMP, Dept Clin Med, Fac Ciencias Med, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RHEUMATOLOGY INTERNATIONAL; v. 32, n. 3, p. 815-818, MAR 2012.
• Citações Web of Science: 3

Resumo

Targeted inhibition of tumor necrosis factor-alpha (TNF-alpha) is an effective therapy in rheumatoid arthritis (RA). In some rare cases, autoimmune phenomena, including drug-induced lupus and vasculitis, is described. However, the immunological mechanisms underlying the development of autoimmunity are unknown. We report 3 patients that developed autoimmune phenomena while in use of TNF-alpha inhibitor, showing concomitant increase in rheumatoid factor (RF). We hypothesize that the increase in RF several months prior to the occurrence of vasculitis may help identifying other patients at risk for the development of vasculitis secondary to these medications. (AU)

• Processo FAPESP: 09/06049-6 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no Lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores