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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis

Full text
Author(s):
Mendonca, Jose Alexandre [1] ; Marques-Neto, Joao Francisco [2] ; Samara, Adil Muhib [2] ; Appenzeller, Simone [2]
Total Authors: 4
Affiliation:
[1] Pontifica Univ Campinas, Rheumatol Serv, Campinas, SP - Brazil
[2] Univ Estadual Campinas UNICAMP, Dept Clin Med, Fac Ciencias Med, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: RHEUMATOLOGY INTERNATIONAL; v. 32, n. 3, p. 815-818, MAR 2012.
Web of Science Citations: 3
Abstract

Targeted inhibition of tumor necrosis factor-alpha (TNF-alpha) is an effective therapy in rheumatoid arthritis (RA). In some rare cases, autoimmune phenomena, including drug-induced lupus and vasculitis, is described. However, the immunological mechanisms underlying the development of autoimmunity are unknown. We report 3 patients that developed autoimmune phenomena while in use of TNF-alpha inhibitor, showing concomitant increase in rheumatoid factor (RF). We hypothesize that the increase in RF several months prior to the occurrence of vasculitis may help identifying other patients at risk for the development of vasculitis secondary to these medications. (AU)

FAPESP's process: 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus
Grantee:Simone Appenzeller
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
Grantee:Simone Appenzeller
Support type: Research Grants - Young Investigators Grants