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Evaluation of rheumatoid arthritis and periodontal disease association. Study of IL-23/IL-17 axis in experimental model of rheumatoid arthritis and periodontal disease in mice.

Grant number: 08/08142-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2008
Effective date (End): January 31, 2012
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Joni Augusto Cirelli
Grantee:Sabrina Garcia de Aquino
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Inflammatory-immune host responses have an important role on homeostasis maintenance, as well as in the beginning and progression of many autoimmune, inflammatory and infectious diseases. Periodontal disease (PD) and rheumatoid arthritis (RA) share many pathological characteristics including changes in the pattern and levels of cytokines and their antagonists. Also, this immune-inflammatory imbalance has been considered responsible for most of tissues destruction observed during the progression of these diseases. A higher PD prevalence has been observed in RA patients, as well as a decreasing of RA severity after infection control with periodontal treatment. Some parameters as RA duration and severity degree, oral hygiene control, gingival inflammation and drugs used for RA patients are discussed as influence factors in PD and RA relationship which still remains controversial. Pro-inflammatory cytokines have a fundamental role in the pathogenesis of both disorders. In this context, recent evidences have suggested a relevant role of the inflammatory axis IL-23/IL-17 in RA pathogenesis through concurrency and/or synergism with other cytokines such as IL-1² and TNF-±, with a subsequent amplification of inflammation and changes in the RANK-RANKL/OPG axis (osteoclastogenesis). The role of Th17 and of IL-23/IL-17 axis in the PD immunopathology is still unknown and poorly investigated. However, a pro-inflammatory activity of IL-17 in the PD pathogenesis as observed for RA has been suggested by papers where higher levels of IL17 were detected in PD sites. In recent literature, studies of PD models for IL-23/IL-17 axis investigation were not found, neither the simultaneous induction of RA and PD with the aim to investigate the relationship between these chronic/inflammatory diseases. Thus, this project has the specific aims: -evaluate the association between PD and RA in experimentally-induced PD and RA by, respectively, bacterial LPS and mBSA, in mice.-evaluate the expression of IL-23 and IL-17 and their role in the physiopathology of PD associated or not to RA in experimentally-induced PD and RA by, respectively, bacterial LPS and mBSA, in IL-17 receptor knock-out mice.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE AQUINO, SABRINA G.; TALBOT, JHIMMY; SONEGO, FABIANE; TURATO, WALTER M.; GRESPAN, RENATA; AVILA-CAMPOS, MARIO J.; CUNHA, FERNANDO Q.; CIRELLI, JONI A. The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 44, n. 9, p. 881-891, SEP 2017. Web of Science Citations: 11.
DE AQUINO, SABRINA G.; ABDOLLAHI-ROODSAZ, SHAHLA; KOENDERS, MARIJE I.; VAN DE LOO, FONS A. J.; PRUIJN, GER J. M.; MARIJNISSEN, RENOUD J.; WALGREEN, BIRGITTE; HELSEN, MONIQUE M.; VAN DEN BERSSELAAR, LIDUINE A.; DE MOLON, RAFAEL S.; AVILA CAMPOS, MARIO J.; CUNHA, FERNANDO Q.; CIRELLI, JONI A.; VAN DEN BERG, WIM B. Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2-and IL-1-Driven Th17 Response. JOURNAL OF IMMUNOLOGY, v. 192, n. 9, p. 4103-4111, MAY 1 2014. Web of Science Citations: 60.

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