miR-15a and 16-1 Are Downregulated in CD4(+) T Cells of Multiple Sclerosis Relapsing Patients

Autor(es)

Cetrulo Lorenzi, Julio Cesar ^{[1, 2]} ; Brum, Doralina G. ^[3] ; Zanette, Dalila L. ^{[1, 2]} ; Alves Souza, Alessandra de Paula ^{[2, 4]} ; Barbuzano, Fernanda Goncalves ^[2] ; dos Santos, Antonio Carlos ^[5] ; Barreira, Amilton Antunes ^[3] ; Silva, Jr., Wilson Araujo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Genet, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

^[2] Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Dept Neurosci, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Dept Immunol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Dept Internal Med, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Neuroscience; v. 122, n. 8, p. 466-471, AUG 2012.
• Citações Web of Science: 32

Resumo

The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/161 in PBMC, CD4(+), and CD8(+) from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4(+) T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4(+) T cells from RR-MS patients, thereby affecting apoptosis processes. (AU)

• Processo FAPESP: 98/14247-6 - Center for Research on Cell-Based Therapy
• Beneficiário: Marco Antonio Zago
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 10/00310-1 - Assinatura de expressão de miRNAs de subpopulações de linfócitos T em indivíduos normais e pacientes com esclerose múltipla
• Beneficiário: Julio Cesar Cetrulo Lorenzi
• Modalidade de apoio: Bolsas no Brasil - Doutorado