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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Epigenetic mechanisms in gastric cancer

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Autor(es):
Gigek, Carolina Oliveira [1] ; Chen, Elizabeth Suchi [1] ; Calcagno, Danielle Queiroz [1] ; Wisnieski, Fernanda [1] ; Burbano, Rommel Rodriguez [2] ; Cardoso Smith, Marilia Arruda [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, Escola Paulista Med, BR-04023900 Sao Paulo - Brazil
[2] Fed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66059 Belem, PA - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Epigenomics; v. 4, n. 3, p. 279-294, JUN 2012.
Citações Web of Science: 72
Resumo

Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. In conclusion, an epigenetic therapy might appear in the not too distant future. (AU)

Processo FAPESP: 09/07145-9 - Aspectos genéticos e epigenéticos na carcinogênese gástrica
Beneficiário:Marilia de Arruda Cardoso Smith
Linha de fomento: Auxílio à Pesquisa - Temático