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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic mechanisms in gastric cancer

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Gigek, Carolina Oliveira [1] ; Chen, Elizabeth Suchi [1] ; Calcagno, Danielle Queiroz [1] ; Wisnieski, Fernanda [1] ; Burbano, Rommel Rodriguez [2] ; Cardoso Smith, Marilia Arruda [1]
Total Authors: 6
[1] Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, Escola Paulista Med, BR-04023900 Sao Paulo - Brazil
[2] Fed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66059 Belem, PA - Brazil
Total Affiliations: 2
Document type: Review article
Source: Epigenomics; v. 4, n. 3, p. 279-294, JUN 2012.
Web of Science Citations: 72

Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. In conclusion, an epigenetic therapy might appear in the not too distant future. (AU)

FAPESP's process: 09/07145-9 - Genetic and epigenetic aspects in gastric carcinogenesis
Grantee:Marilia de Arruda Cardoso Smith
Support type: Research Projects - Thematic Grants