The Effects of Green Tea Consumption on Cardiometabolic Alterations Induced by Experimental Diabetes

Autor(es)

Fiorino, Patricia ^[1] ; Evangelista, Fabiana Sant'Anna ^[2] ; Santos, Fernando ^[1] ; Motter Magri, Fatima Maria ^[1] ; Delorenzi, Jan Carlo Morais O. B. ^[1] ; Ginoza, Milton ^[1] ; Farah, Vera ^[1]

Afiliação do(s) autor(es)

^[1] Univ Prebiteriana Mackenzie, Renal Cardiovasc & Metab Physiopharmacol Lab, Hlth & Biol Sci Ctr, BR-01302907 Sao Paulo - Brazil

^[2] Univ Prebiteriana Mackenzie, Sch Arts Sci & Humanities, BR-01302907 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Diabetes Research; 2012.
• Citações Web of Science: 7

Resumo

We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), and metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar rats were separated in groups: control, drinking tap water (C), green tea-treated (GT) group, diabetic, drinking tap water (D), and diabetic, treated with green tea (DGT). Kidney mass was greater in D and DGT than in C and GT, but reduced in DGT compared to D. Green tea prevented the increase in creatinine clearance and reduced hyperglycemia in DGT compared to D. Arterial pressure was increased in GT and decreased in D compared to C. HRV was reduced in D compared with all groups. APV was decreased in D compared to C and recovery in DGT. Sympathetic modulation of APV was decreased in D compared with all groups. Green tea reduced hyperglycemia, prevented renal injury and autonomic dysfunction, suggesting reduced cardiovascular risk and target organ damage in diabetes. (AU)

• Processo FAPESP: 11/02126-6 - Repercussão metabólica da ativação da AMPK induzida pelo treinamento físico em camundongos submetidos à dieta hipercalórica
• Beneficiário: Fabiana de Sant'Anna Evangelista
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/52556-7 - Influência dos níveis de sal no perfil renal e na função cardiovascular em um modelo experimental de resistência à insulina: papel do sistema renina-angiotensina
• Beneficiário: vera de moura azevedo farah
• Modalidade de apoio: Auxílio à Pesquisa - Regular