Genetic Control of IL-1 beta Production and Inflammatory Response by the Mouse Irm1 Locus

Autor(es):Mostrar menos -

Vorraro, Francisca ^[1] ; Galvan, Antonella ^[2] ; Koury Cabrera, Wafa Hanna ^[1] ; Carneiro, Patricia Santos ^[1] ; Ribeiro, Orlando Garcia ^[1] ; De Franco, Marcelo ^[1] ; Starobinas, Nancy ^[1] ; Jensen, Jose Ricardo ^[1] ; Seman, Michel ^[3] ; Dragani, Tommaso A. ^[2] ; Martinez Ibanez, Olga Celia ^[1]

Afiliação do(s) autor(es)

^[1] Inst Butantan, Immunogenet Lab, BR-05503900 Sao Paulo - Brazil

^[2] Ist Nazl Tumori, Fdn Inst Ricovero & Cura Carattere Sci, Dipartimento Med Preditt & Prevenz, I-20133 Milan - Italy

^[3] Univ Rouen, Dept Immunol, F-76821 Mont St Aignan - France

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY; v. 185, n. 3, p. 1616-1621, AUG 1 2010.
• Citações Web of Science: 10

Resumo

Genome-wide linkage analysis using single nucleotide polymorphism arrays was carried out in pedigrees of mice differing in the extent of acute inflammatory response (AIRmax or AIRmin). The AIR phenotype was determined by quantifying the number of infiltrating cells in the 24-h exudate induced by Biogel P-100 s.c. injection and by ex vivo IL-1 beta production by leukocytes stimulated with LPS and ATP. We mapped the major inflammatory response modulator 1 locus on chromosome 7, at the 1-logarithm of odds (LOD) confidence interval from 116.75 to 139.75 Mb, linked to the number of infiltrating cells (LOD = 3.61) through the production of IL-1 beta (LOD = 9.35). Of several interesting candidate genes mapping to the inflammatory response modulator 1 locus, 28 of these were differentially expressed in the bone marrow of AIRmax and AIRmin mice. These findings represent a step toward the identification of the genes underlying this complex phenotype. The Journal of Immunology, 2010, 185: 1616-1621. (AU)

• Processo FAPESP: 03/05486-7 - Determinação de fatores genéticos que afetam a resistência ou susceptibilidade à carcinogênese química e à intensidade da resposta inflamatória aguda, empregando modelo de linhagens de camundongos
• Beneficiário: Olga Celia Martinez Ibanez
• Modalidade de apoio: Auxílio à Pesquisa - Temático