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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Control of IL-1 beta Production and Inflammatory Response by the Mouse Irm1 Locus

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Author(s):
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Vorraro, Francisca [1] ; Galvan, Antonella [2] ; Koury Cabrera, Wafa Hanna [1] ; Carneiro, Patricia Santos [1] ; Ribeiro, Orlando Garcia [1] ; De Franco, Marcelo [1] ; Starobinas, Nancy [1] ; Jensen, Jose Ricardo [1] ; Seman, Michel [3] ; Dragani, Tommaso A. [2] ; Martinez Ibanez, Olga Celia [1]
Total Authors: 11
Affiliation:
[1] Inst Butantan, Immunogenet Lab, BR-05503900 Sao Paulo - Brazil
[2] Ist Nazl Tumori, Fdn Inst Ricovero & Cura Carattere Sci, Dipartimento Med Preditt & Prevenz, I-20133 Milan - Italy
[3] Univ Rouen, Dept Immunol, F-76821 Mont St Aignan - France
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF IMMUNOLOGY; v. 185, n. 3, p. 1616-1621, AUG 1 2010.
Web of Science Citations: 10
Abstract

Genome-wide linkage analysis using single nucleotide polymorphism arrays was carried out in pedigrees of mice differing in the extent of acute inflammatory response (AIRmax or AIRmin). The AIR phenotype was determined by quantifying the number of infiltrating cells in the 24-h exudate induced by Biogel P-100 s.c. injection and by ex vivo IL-1 beta production by leukocytes stimulated with LPS and ATP. We mapped the major inflammatory response modulator 1 locus on chromosome 7, at the 1-logarithm of odds (LOD) confidence interval from 116.75 to 139.75 Mb, linked to the number of infiltrating cells (LOD = 3.61) through the production of IL-1 beta (LOD = 9.35). Of several interesting candidate genes mapping to the inflammatory response modulator 1 locus, 28 of these were differentially expressed in the bone marrow of AIRmax and AIRmin mice. These findings represent a step toward the identification of the genes underlying this complex phenotype. The Journal of Immunology, 2010, 185: 1616-1621. (AU)

FAPESP's process: 03/05486-7 - Identification of genetic factors affecting resistance and susceptibility to chemical carcinogenesis and the degree of acute inflammatory response, using a model of genetically selected mouse lines
Grantee:Olga Celia Martinez Ibanez
Support Opportunities: Research Projects - Thematic Grants