Inhibition of Mouse Urinary Bladder Carcinogenesis by A double dagger ai Fruit (Euterpe oleraceae Martius) Intake

Autor(es)

Fragoso, Mariana F. ^[1] ; Prado, Monize G. ^[2] ; Barbosa, Luciano ^[3] ; Rocha, Noeme S. ^[4] ; Barbisan, Luis F. ^{[5, 2]}

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Postgrad Program Pathol, Fac Med, BR-18618097 Botucatu, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Dept Morphol, Inst Biosci, BR-18618097 Botucatu, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Dept Biostat, Inst Biosci, BR-18618097 Botucatu, SP - Brazil

^[4] UNESP Sao Paulo State Univ, Dept Vet Clin, Fac Vet Med, BR-18618097 Botucatu, SP - Brazil

^[5] Univ Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618097 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLANT FOODS FOR HUMAN NUTRITION; v. 67, n. 3, p. 235-241, SEP 2012.
• Citações Web of Science: 18

Resumo

A double dagger ai, fruit from Euterpe oleraceae Martius, is consumed in natura and in a variety of beverages and food preparations and possesses several potential antioxidant compounds. In a first study for anticarcinogenicity screening, male Swiss mice (n = 20/per group) were chemically-induced to urothelial bladder carcinogenesis for 10 weeks and received a standard diet or a standard diet containing 2.5 and 5 % spray-dried a double dagger ai pulp (AP) for 10 weeks. At week 20, the incidence of simple and nodular hyperplasia and the incidence and multiplicity of transitional cell carcinoma (TCC) were evaluated. In a second study for antigenotoxicity screening, male Swiss mice (n = 6/per group) were fed standard diet or standard diet containing 5 % AP for three weeks. Urothelial cell suspensions were obtained and challenged with H2O2 for induction of DNA damage and analyzed by comet assay. Overall, dietary 5 % AP reduced TCC incidence and multiplicity (p = 0.019 and p = 0.015, respectively) and tumor cell proliferation and p63 expression (p = 0.02 and p = 0.007, respectively), Furthermore, the group fed the 5 % AP presented a significant reduction (p < 0.01) in DNA damage induced by H2O2, a notable oxidant agent. The results suggest that the spray-dried a double dagger ai pulp used here inhibits the TCC development in male Swiss mice, probably due to its potential antioxidant action. (AU)

• Processo FAPESP: 09/50890-7 - Influência do consumo do café (com e sem cafeína) ou da cafeína sobre a hepatotoxicidade induzida pela tiocetamida em ratos Wistar machos
• Beneficiário: Monize Gonçalves do Prado
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/54858-5 - Influencia do consumo do cafe (com e sem cafeina) ou da cafeina isolada sobre a fibrose e a promocao da hepatocarcinogenese quimica em ratos wistar machos.
• Beneficiário: Kelly Silva Furtado
• Modalidade de apoio: Bolsas no Brasil - Doutorado