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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inhibition of Mouse Urinary Bladder Carcinogenesis by A double dagger ai Fruit (Euterpe oleraceae Martius) Intake

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Author(s):
Fragoso, Mariana F. [1] ; Prado, Monize G. [2] ; Barbosa, Luciano [3] ; Rocha, Noeme S. [4] ; Barbisan, Luis F. [5, 2]
Total Authors: 5
Affiliation:
[1] UNESP Sao Paulo State Univ, Postgrad Program Pathol, Fac Med, BR-18618097 Botucatu, SP - Brazil
[2] UNESP Sao Paulo State Univ, Dept Morphol, Inst Biosci, BR-18618097 Botucatu, SP - Brazil
[3] UNESP Sao Paulo State Univ, Dept Biostat, Inst Biosci, BR-18618097 Botucatu, SP - Brazil
[4] UNESP Sao Paulo State Univ, Dept Vet Clin, Fac Vet Med, BR-18618097 Botucatu, SP - Brazil
[5] Univ Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618097 Botucatu, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PLANT FOODS FOR HUMAN NUTRITION; v. 67, n. 3, p. 235-241, SEP 2012.
Web of Science Citations: 18
Abstract

A double dagger ai, fruit from Euterpe oleraceae Martius, is consumed in natura and in a variety of beverages and food preparations and possesses several potential antioxidant compounds. In a first study for anticarcinogenicity screening, male Swiss mice (n = 20/per group) were chemically-induced to urothelial bladder carcinogenesis for 10 weeks and received a standard diet or a standard diet containing 2.5 and 5 % spray-dried a double dagger ai pulp (AP) for 10 weeks. At week 20, the incidence of simple and nodular hyperplasia and the incidence and multiplicity of transitional cell carcinoma (TCC) were evaluated. In a second study for antigenotoxicity screening, male Swiss mice (n = 6/per group) were fed standard diet or standard diet containing 5 % AP for three weeks. Urothelial cell suspensions were obtained and challenged with H2O2 for induction of DNA damage and analyzed by comet assay. Overall, dietary 5 % AP reduced TCC incidence and multiplicity (p = 0.019 and p = 0.015, respectively) and tumor cell proliferation and p63 expression (p = 0.02 and p = 0.007, respectively), Furthermore, the group fed the 5 % AP presented a significant reduction (p < 0.01) in DNA damage induced by H2O2, a notable oxidant agent. The results suggest that the spray-dried a double dagger ai pulp used here inhibits the TCC development in male Swiss mice, probably due to its potential antioxidant action. (AU)