Galleria mellonella as a model host for human pathogens

Autor(es)

Junqueira, Juliana Campos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: VIRULENCE; v. 3, n. 6, p. 474-476, OCT 2012.
• Citações Web of Science: 40

Resumo

The number of studies using G. mellonella as a model host for human pathogens has increased significantly in the last few years. Important studies were published from different countries for evaluating the pathogenesis of bacterial and fungal infections and for exploring the host defenses against pathogens. Therefore, standardized conditions for the use of G. melonella larvae need to be established. Recent research showed that the deprivation of G. mellonella larvae of food during the experiment caused a reduction in immune responses and an increased susceptibility to infection, suggesting that incubating of larvae in the presence or absence of nutrition may affect the results and comparisons among different laboratories. (AU)

• Processo FAPESP: 12/02184-9 - Interações entre diferentes espécies de Candida na candidose experimental em modelos de invertebrados e vertebrados
• Beneficiário: Juliana Campos Junqueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular