| Texto completo | |
| Autor(es): |
Figueiredo, Jozi
[1]
;
Ferreira, Ana Elisa
[1]
;
Silva, Rangel Leal
[1]
;
Ulloa, Luis
[2]
;
Grieco, Paolo
[3]
;
Cunha, Thiago Mattar
[1]
;
Ferreira, Sergio Henrique
[1]
;
Cunha, Fernando de Queiroz
[1]
;
Kanashiro, Alexandre
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pharmacol, Fac Med Ribeirao Preto, BR-14049 90 Sao Paulo - Brazil
[2] UMDNJ New Jersey Med Sch, Dept Surg, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 - USA
[3] Univ Naples Federico II, Dept Pharmaceut & Toxicol Chem, I-80131 Naples - Italy
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY; v. 386, n. 4, p. 311-318, APR 2013. |
| Citações Web of Science: | 7 |
| Resumo | |
Melanocortin is a potent anti-inflammatory molecule. However, little is known about the effect of melanocortin on acute inflammatory processes such as neutrophil migration. In the present study, we investigated the ability of {[}Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model. Herein, subcutaneous pretreatment with NDP-MSH decreased neutrophil trafficking in the peritoneal cavity in a dose-dependent manner. NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production. In addition, the effect on neutrophil migration was reverted by the pretreatment with both propranolol (a nonselective beta-adrenergic antagonist) and mecamylamine (a nonselective nicotinic antagonist) but not by splenectomy surgery. Moreover, NDP-MSH intracerebroventricular administration inhibited neutrophil migration, indicating participation of the central nervous system. Our results propose that the NDP-MSH effect may be due to a spleen-independent neuro-immune pathway that efficiently regulates excessive neutrophil recruitment to tissues. (AU) | |
| Processo FAPESP: | 12/04237-2 - Via Colinérgica Anti-inflamatória: O papel da neuroimunomodulação no controle da resposta Inflamatória. |
| Beneficiário: | Alexandre Kanashiro |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |
| Processo FAPESP: | 11/11931-0 - Investigação dos canais de potássio voltagem-dependentes na indução e manutenção da Hipernocicepção persistente e neuropática. |
| Beneficiário: | Jozi Godoy Figueiredo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 11/20343-4 - Via colinérgica anti-inflamatória: o papel da neuroimunomodulação no controle da resposta inflamatória |
| Beneficiário: | Alexandre Kanashiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |