Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task

Autor(es)

Zanin, Karina A. ^{[1, 2]} ; Patti, Camilla L. ^{[1, 2]} ; Sanday, Leandro ^[1] ; Fernandes-Santos, Luciano ^{[1, 2]} ; Oliveira, Larissa C. ^[1] ; Poyares, Dalva ^[2] ; Tufik, Sergio ^[2] ; Frussa-Filho, Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Psychopharmacology; v. 226, n. 3, p. 459-474, APR 2013.
• Citações Web of Science: 8

Resumo

Zolpidem (Zolp), a hypnotic drug prescribed to treat insomnia, may have negative effects on memory, but reports are inconsistent. We examined the effects of acute doses of Zolp (2, 5, or 10 mg/kg, i.p.) on memory formation (learning, consolidation, and retrieval) using the plus-maze discriminative avoidance task. Mice were acutely treated with Zolp 30 min before training or testing. In addition, the effects of Zolp and midazolam (Mid; a classic benzodiazepine) on consolidation at different time points were examined. The possible role of state dependency was investigated using combined pre-training and pre-test treatments. Zolp produced a dose-dependent sedative effect, without modifying anxiety-like behavior. The pre-training administration of 5 or 10 mg/kg resulted in retention deficits. When administered immediately after training or before testing, memory was preserved. Zolp post-training administration (2 or 3 h) impaired subsequent memory. There was no participation of state dependency phenomenon in the amnestic effects of Zolp. Similar to Zolp, Mid impaired memory consolidation when administered 1 h after training. Amnestic effects occurred when Zolp was administered either before or 2-3 h after training. These memory deficits are not related to state dependency. Moreover, Zolp did not impair memory retrieval. Notably, the memory-impairing effects of Zolp are similar to those of Mid, with the exception of the time point at which the drug can modify consolidation. Finally, the memory effects were unrelated to sedation or anxiolysis. (AU)

• Processo FAPESP: 08/08823-8 - Efeitos do zolpidem sobre o aprendizado e a memória de camundongos avaliados no modelo da esquiva discriminativa em labirinto em cruz elevado
• Beneficiário: Karina Agustini Zanin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/00465-8 - Caracterização experimental dos efeitos amnésticos imediatos ou tardios promovidos pela privação parcial crônica de sono paradoxal ou total em camundongos: aspectos comportamentais, moleculares e genéticos
• Beneficiário: Camilla de Lima Patti Hissamura
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs