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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuropathology and behavioral impairments after bilateral global ischemia surgery and exposure to static magnetic field: Evidence in the motor cortex, the hippocampal CA1 region and the neostriatum

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Autor(es):
Bertolino, Guilherme [1] ; Buiatti De Araujo, Fernanda Lopes [1] ; Dutra Souza, Hugo Celso [1] ; Coimbra, Norberto Cysne [2] ; De Araujo, Joao Eduardo [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Biomech Med & Rehabil Locomotor Syst, Ribeirao Preto Med Sch, Lab Neuropsychobiol & Motor Behav, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Ribeirao Preto Med Sch, Lab Neuroanat & Neuropsychobiol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: International Journal of Radiation Biology; v. 89, n. 8, p. 595-601, AUG 2013.
Citações Web of Science: 8
Resumo

3 Purpose : To evaluate the effects of continuous magnetic field stimulation after four days of global encephalic ischemia on motor behavior and brain morphology in gerbils. Material and methods : Sixty Mongolian gerbils were divided into five groups: Control (CG), sham (SG), ischemia (IG), ischemia north (INPG) and south (ISPG) pole. Experimental animals underwent bilateral occlusion of the carotid artery. In groups with magnetic stimulation, a 3200 gauss magnet was fixed to the skull. After brain perfusion, coronal sections of the striatum, motor cortex (M1) and CA1 area of the hippocampus (CA1) were cut and stained with hematoxylin and eosin. Results : In the open field test (OF) we observed an increase in crossing in the IG compared to the CG, INPG and ISPG (F = 20.19), and a reduction in the time spent on the Rota-rod test (RR) with the IG compared to CG, IPNG and ISPG (F = 17.59). Morphometric analysis revealed a reduction in the density of the neurons in the CA1, in the number of M1 and striatal neurons in the IG compared to the CG, INPG and ISPG. Conclusion : Our results demonstrate a potential therapeutic application of static magnetic fields for the preservation of motor behavior and neurons in regions analyzed after global cerebral ischemia. (AU)

Processo FAPESP: 07/04560-0 - Efeitos comportamentais e alterações apoptóticas neuroniais eliciadas pelo campo magnético contínuo em diferentes regiões do sistema nervoso central após lesões experimentalmente induzidas
Beneficiário:João Eduardo de Araujo
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores