Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: A randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer

Autor(es)

Matos de Miranda Torrinhas, Raquel Susana ^{[1, 2]} ; Santana, Raquel ^[1] ; Garcia, Thais ^[1] ; Cury-Boaventura, Maria Fernanda ; Sales, Maria Mirtes ^[3] ; Curi, Rui ^[4] ; Waitzberg, Dan Linetzky ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Gastroenterol, Med Sch LIM 35, BR-01245903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Food & Nutr Res Ctr NAPAN, BR-01245903 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sect Flow Cytometry, Dept Hematol, Clin Hosp, BR-01245903 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-01245903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Nutrition; v. 32, n. 4, p. 503-510, AUG 2013.
• Citações Web of Science: 28

Resumo

Background: Fish oil-based lipid emulsions (FOLEs) have shown post-operative immunological and clinical benefits in parenteral nutrition. Aim: To assess post-operative immune response after short-term pre-operative parenteral infusion of isolated FOLE in gastrointestinal cancer patients. Methods: The patients (n = 63) received pre-operative peripheral infusion (0.2 g fat/kg body weight/d) of FOLE (Omegaven (R)) or control lipid emulsion (MCT/LCT; Lipovenos MCT (R)) for 3 days. Post-operative concentrations of inflammatory mediators, leukocyte functions, surface molecules, infections, and length of intensive care unit (ICU) and hospital stay were measured. Results: FOLE patients had a significant increase of IL-10 levels on day 3, decrease of IL-6 and IL-10 levels on day 6, lower decrease in leukocyte oxidative burst, maintenance of monocyte percentage expressing HLA-DR and CD32, and increase of CD32 neutrophil expression compared to MCT/LCT patients. No changes were observed in the frequency of post-operative infections or length of ICU and hospital stay. Conclusions: Short-term pre-operative infusion of FO alone improves the post-operative immune response of gastrointestinal cancer patients without significantly changing post-operative infections or length of ICU and hospital stay. ID:NCT01218841. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)

• Processo FAPESP: 07/56474-0 - Desenvolvimento de tecnica de citometria de fluxo para avaliacao da expressao de moleculas envolvidas no processo de apresentacao de antigenos na superficie deleucocitos de pacientes com cancer no...
• Beneficiário: Thais Garcia Silveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 04/06259-7 - Efeito da oferta pré-operatória de ácidos graxos w-3 parenterais sobre a produção de citocinas pró-inflamatórias e a expressão de moléculas de superfície com funções imunes e atividade funcional de fagócitos de pacientes desnutridos com câncer de estômago
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/50944-7 - Avaliação dos níveis de citocinas plasmáticas de pacientes com câncer no aparelho digestivo tratados com ácidos graxos ômega-3 parenterais por método de ELISA
• Beneficiário: Raquel Santana da Cruz
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica