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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: A randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer

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Author(s):
Matos de Miranda Torrinhas, Raquel Susana [1, 2] ; Santana, Raquel [1] ; Garcia, Thais [1] ; Cury-Boaventura, Maria Fernanda ; Sales, Maria Mirtes [3] ; Curi, Rui [4] ; Waitzberg, Dan Linetzky [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Gastroenterol, Med Sch LIM 35, BR-01245903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Food & Nutr Res Ctr NAPAN, BR-01245903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sect Flow Cytometry, Dept Hematol, Clin Hosp, BR-01245903 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-01245903 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinical Nutrition; v. 32, n. 4, p. 503-510, AUG 2013.
Web of Science Citations: 28
Abstract

Background: Fish oil-based lipid emulsions (FOLEs) have shown post-operative immunological and clinical benefits in parenteral nutrition. Aim: To assess post-operative immune response after short-term pre-operative parenteral infusion of isolated FOLE in gastrointestinal cancer patients. Methods: The patients (n = 63) received pre-operative peripheral infusion (0.2 g fat/kg body weight/d) of FOLE (Omegaven (R)) or control lipid emulsion (MCT/LCT; Lipovenos MCT (R)) for 3 days. Post-operative concentrations of inflammatory mediators, leukocyte functions, surface molecules, infections, and length of intensive care unit (ICU) and hospital stay were measured. Results: FOLE patients had a significant increase of IL-10 levels on day 3, decrease of IL-6 and IL-10 levels on day 6, lower decrease in leukocyte oxidative burst, maintenance of monocyte percentage expressing HLA-DR and CD32, and increase of CD32 neutrophil expression compared to MCT/LCT patients. No changes were observed in the frequency of post-operative infections or length of ICU and hospital stay. Conclusions: Short-term pre-operative infusion of FO alone improves the post-operative immune response of gastrointestinal cancer patients without significantly changing post-operative infections or length of ICU and hospital stay. ID:NCT01218841. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)