Zoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells

Autor(es)

Basso, Fernanda G. ^[1] ; Turrioni, Ana Paula S. ^[2] ; Hebling, Josimeri ^[2] ; de Souza Costa, Carlos Alberto ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Sch Dent, BR-13414903 Piracicaba, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Araraquara Sch Dent, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY; v. 51, n. 8, p. 971-973, DEC 2013.
• Citações Web of Science: 5

Resumo

Delayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bEGF) by epithelial cells exposed to zoledronic acid 5 mu mol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells. (C) 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/52326-1 - Avaliação in vitro dos efeitos da laserterapia de baixa intensidade sobre cultura de osteoblastos, fibroblastos e queratinócitos submetidos ao tratamento com ácido zoledrônico
• Beneficiário: Fernanda Gonçalves Basso
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/54722-1 - Avaliação in vitro dos efeitos da laserterapia de baixa intensidade sobre cultura de osteoblastos, fibroblastos e queratinócitos submetidos ao tratamento com ácido zoledrônico
• Beneficiário: Carlos Alberto de Souza Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular