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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells

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Author(s):
Basso, Fernanda G. [1] ; Turrioni, Ana Paula S. [2] ; Hebling, Josimeri [2] ; de Souza Costa, Carlos Alberto [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Sch Dent, BR-13414903 Piracicaba, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Araraquara Sch Dent, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY; v. 51, n. 8, p. 971-973, DEC 2013.
Web of Science Citations: 5
Abstract

Delayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bEGF) by epithelial cells exposed to zoledronic acid 5 mu mol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells. (C) 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/54722-1 - In vitro evaluation of the effects of low level laser therapy on cultured osteoblasts, fibroblasts and keratonicytes submitted to zoledronic acid therapy
Grantee:Carlos Alberto de Souza Costa
Support Opportunities: Regular Research Grants