Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuroprotective Properties of the Marine Carotenoid Astaxanthin and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil

Texto completo
Autor(es):
Barros, Marcelo P. [1, 2] ; Poppe, Sandra C. [1, 3] ; Bondan, Eduardo F. [3, 2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Cruzeiro do Sul Univ, Inst Phys Act & Sports Sci ICAFE, BR-01506000 Sao Paulo - Brazil
[2] Cruzeiro do Sul Univ, Grad Program Hlth Sci, BR-01506000 Sao Paulo - Brazil
[3] Univ Paulista UNIP, Dept Vet Med, BR-01506000 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: NUTRIENTS; v. 6, n. 3, p. 1293-1317, MAR 2014.
Citações Web of Science: 38
Resumo

The consumption of marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve mental health, hinder neurodegenerative processes, and sustain cognitive capacities in humans. Most of the neurological benefits provided by frequent seafood consumption comes from adequate uptake of omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, and antioxidants. Optimal n-3/n-6 PUFAs ratios allow efficient inflammatory responses that prevent the initiation and progression of many neurological disorders. Moreover, interesting in vivo and clinical studies with the marine antioxidant carotenoid astaxanthin (present in salmon, shrimp, and lobster) have shown promising results against free radical-promoted neurodegenerative processes and cognition loss. This review presents the state-of-the-art applications of n-3/n-6 PUFAs and astaxanthin as nutraceuticals against neurodegenerative diseases associated with exacerbated oxidative stress in CNS. The fundamental neurohormesis principle is discussed throughout this paper. Finally, new perspectives for the application of a natural combination of the aforementioned anti-inflammatory and antioxidant agents (found in krill oil) are also presented herewith. (AU)

Processo FAPESP: 02/09405-9 - Estudo da atividade antioxidante da astaxantina em lipossomos unilamelares: bloqueando radicais livres e afetando a permeabilidade da membrana?
Beneficiário:Marcelo Paes de Barros
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 09/12342-8 - Ação do carotenóide astaxantina na regulação do equilíbrio redox no músculo esquelético de ratos sob atividade física exaustiva (natação): projeto AstaSwim
Beneficiário:Andréa Ramalho Mihaliuc
Linha de fomento: Bolsas no Brasil - Mestrado