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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroprotective Properties of the Marine Carotenoid Astaxanthin and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil

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Author(s):
Barros, Marcelo P. [1, 2] ; Poppe, Sandra C. [1, 3] ; Bondan, Eduardo F. [3, 2]
Total Authors: 3
Affiliation:
[1] Cruzeiro do Sul Univ, Inst Phys Act & Sports Sci ICAFE, BR-01506000 Sao Paulo - Brazil
[2] Cruzeiro do Sul Univ, Grad Program Hlth Sci, BR-01506000 Sao Paulo - Brazil
[3] Univ Paulista UNIP, Dept Vet Med, BR-01506000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: NUTRIENTS; v. 6, n. 3, p. 1293-1317, MAR 2014.
Web of Science Citations: 38
Abstract

The consumption of marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve mental health, hinder neurodegenerative processes, and sustain cognitive capacities in humans. Most of the neurological benefits provided by frequent seafood consumption comes from adequate uptake of omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, and antioxidants. Optimal n-3/n-6 PUFAs ratios allow efficient inflammatory responses that prevent the initiation and progression of many neurological disorders. Moreover, interesting in vivo and clinical studies with the marine antioxidant carotenoid astaxanthin (present in salmon, shrimp, and lobster) have shown promising results against free radical-promoted neurodegenerative processes and cognition loss. This review presents the state-of-the-art applications of n-3/n-6 PUFAs and astaxanthin as nutraceuticals against neurodegenerative diseases associated with exacerbated oxidative stress in CNS. The fundamental neurohormesis principle is discussed throughout this paper. Finally, new perspectives for the application of a natural combination of the aforementioned anti-inflammatory and antioxidant agents (found in krill oil) are also presented herewith. (AU)

FAPESP's process: 09/12342-8 - The carotenoid astaxanthin as a redox switch in muscle tissues of rats submitted to exhaustive swimming exercise: the AstaSwim project
Grantee:Andréa Ramalho Mihaliuc
Support Opportunities: Scholarships in Brazil - Master