Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine

Autor(es)

Furtado, Kelly S. ^[1] ; Polletini, Jossimara ^[1] ; Dias, Marcos C. ^[1] ; Rodrigues, Maria A. M. ^[1] ; Barbisan, Luis F. ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Dept Pathol, Sch Med, BR-18618970 Sao Paulo - Brazil

^[2] UNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, BR-18618970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 64, p. 20-26, FEB 2014.
• Citações Web of Science: 16

Resumo

Coffee has been inversely related to the incidence of human liver disease; however, whether caffeine is the component responsible for the beneficial effects of coffee remains controversial. This study evaluated the beneficial effects of coffee or caffeine in a medium-term bioassay for rat liver fibrosis/carcinogenesis induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl4). One week after the DEN injection, the groups started to receive conventional coffee, instant coffee or 0.1% caffeine ad libitum for 24 weeks. The groups receiving conventional coffee or caffeine presented a significant reduction in collagen content and mRNA expression of collagen I. The groups receiving instant coffee or caffeine had a significant reduction in the size and area of pre-neoplastic lesions and in the mean number of neoplastic lesions. A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group. These data indicate that the most pronounced hepatoprotective effect against fibrosis was observed in the groups receiving conventional coffee and 0.1% caffeine, and the greatest effects against liver carcinogenesis were detected in the groups receiving instant coffee and 0.1% caffeine. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/50985-5 - Avaliação da atividade moduladora do café/cafeina e da Ginkgo biloba sobre o processo de carcinogênese química em diferentes modelos experimentais
• Beneficiário: Luís Fernando Barbisan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/50890-7 - Influência do consumo do café (com e sem cafeína) ou da cafeína sobre a hepatotoxicidade induzida pela tiocetamida em ratos Wistar machos
• Beneficiário: Monize Gonçalves do Prado
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/54858-5 - Influencia do consumo do cafe (com e sem cafeina) ou da cafeina isolada sobre a fibrose e a promocao da hepatocarcinogenese quimica em ratos wistar machos.
• Beneficiário: Kelly Silva Furtado
• Modalidade de apoio: Bolsas no Brasil - Doutorado