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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine

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Author(s):
Furtado, Kelly S. [1] ; Polletini, Jossimara [1] ; Dias, Marcos C. [1] ; Rodrigues, Maria A. M. [1] ; Barbisan, Luis F. [2]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Dept Pathol, Sch Med, BR-18618970 Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, BR-18618970 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Food and Chemical Toxicology; v. 64, p. 20-26, FEB 2014.
Web of Science Citations: 16
Abstract

Coffee has been inversely related to the incidence of human liver disease; however, whether caffeine is the component responsible for the beneficial effects of coffee remains controversial. This study evaluated the beneficial effects of coffee or caffeine in a medium-term bioassay for rat liver fibrosis/carcinogenesis induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl4). One week after the DEN injection, the groups started to receive conventional coffee, instant coffee or 0.1% caffeine ad libitum for 24 weeks. The groups receiving conventional coffee or caffeine presented a significant reduction in collagen content and mRNA expression of collagen I. The groups receiving instant coffee or caffeine had a significant reduction in the size and area of pre-neoplastic lesions and in the mean number of neoplastic lesions. A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group. These data indicate that the most pronounced hepatoprotective effect against fibrosis was observed in the groups receiving conventional coffee and 0.1% caffeine, and the greatest effects against liver carcinogenesis were detected in the groups receiving instant coffee and 0.1% caffeine. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/50985-5 - Evaluation of modulating activity of coffee/caffeine and Ginkgo biloba on chemical carcinogenesis process in different experimental models
Grantee:Luís Fernando Barbisan
Support Opportunities: Regular Research Grants