Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Autor(es):Mostrar menos -

Leanca, Camila C. ^[1] ; Nunes, Valeria S. ^[1] ; Panzoldo, Natalia B. ^[2] ; Zago, Vanessa S. ^[2] ; Parra, Eliane S. ^[2] ; Cazita, Patricia M. ^[1] ; Jauhiainen, Matti ^[3] ; Passarelli, Marisa ^[1] ; Nakandakare, Edna R. ^[1] ; de Faria, Eliana C. ^[2] ; Quintao, Eder C. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Sci, Hosp Clin, Div Endocrinol & Metab, Lipids Lab LIM 10, BR-0124600 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil

^[3] Natl Inst Hlth & Welf, Publ Hlth Genom Res Unit, Helsinki - Finland

• Tipo de documento: Artigo Científico
• Fonte: CARDIOVASCULAR DIABETOLOGY; v. 12, NOV 22 2013.
• Citações Web of Science: 10

Resumo

Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (AU)

• Processo FAPESP: 08/50185-9 - O metabolismo de lipoproteínas e a sensibilidade a insulina são distintamente modulados em indivíduos saudáveis com concentração alta ou baixa de HDL-colesterol
• Beneficiário: Camila Canteiro Leança
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
• Beneficiário: Eder Carlos Rocha Quintão
• Modalidade de apoio: Auxílio à Pesquisa - Temático