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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

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Autor(es):
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Leanca, Camila C. [1] ; Nunes, Valeria S. [1] ; Panzoldo, Natalia B. [2] ; Zago, Vanessa S. [2] ; Parra, Eliane S. [2] ; Cazita, Patricia M. [1] ; Jauhiainen, Matti [3] ; Passarelli, Marisa [1] ; Nakandakare, Edna R. [1] ; de Faria, Eliana C. [2] ; Quintao, Eder C. R. [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Sci, Hosp Clin, Div Endocrinol & Metab, Lipids Lab LIM 10, BR-0124600 Sao Paulo - Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[3] Natl Inst Hlth & Welf, Publ Hlth Genom Res Unit, Helsinki - Finland
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CARDIOVASCULAR DIABETOLOGY; v. 12, NOV 22 2013.
Citações Web of Science: 10
Resumo

Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (AU)

Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
Beneficiário:Eder Carlos Rocha Quintão
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 08/50185-9 - O metabolismo de lipoproteínas e a sensibilidade a insulina são distintamente modulados em indivíduos saudáveis com concentração alta ou baixa de HDL-colesterol
Beneficiário:Camila Canteiro Leança
Linha de fomento: Bolsas no Brasil - Doutorado Direto