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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

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Leanca, Camila C. [1] ; Nunes, Valeria S. [1] ; Panzoldo, Natalia B. [2] ; Zago, Vanessa S. [2] ; Parra, Eliane S. [2] ; Cazita, Patricia M. [1] ; Jauhiainen, Matti [3] ; Passarelli, Marisa [1] ; Nakandakare, Edna R. [1] ; de Faria, Eliana C. [2] ; Quintao, Eder C. R. [1]
Total Authors: 11
[1] Univ Sao Paulo, Fac Med Sci, Hosp Clin, Div Endocrinol & Metab, Lipids Lab LIM 10, BR-0124600 Sao Paulo - Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[3] Natl Inst Hlth & Welf, Publ Hlth Genom Res Unit, Helsinki - Finland
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 10

Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (AU)

FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
Grantee:Eder Carlos Rocha Quintão
Support type: Research Projects - Thematic Grants