| Full text | |
| Author(s): Show less - |
Leanca, Camila C.
[1]
;
Nunes, Valeria S.
[1]
;
Panzoldo, Natalia B.
[2]
;
Zago, Vanessa S.
[2]
;
Parra, Eliane S.
[2]
;
Cazita, Patricia M.
[1]
;
Jauhiainen, Matti
[3]
;
Passarelli, Marisa
[1]
;
Nakandakare, Edna R.
[1]
;
de Faria, Eliana C.
[2]
;
Quintao, Eder C. R.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Sci, Hosp Clin, Div Endocrinol & Metab, Lipids Lab LIM 10, BR-0124600 Sao Paulo - Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[3] Natl Inst Hlth & Welf, Publ Hlth Genom Res Unit, Helsinki - Finland
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | CARDIOVASCULAR DIABETOLOGY; v. 12, NOV 22 2013. |
| Web of Science Citations: | 10 |
| Abstract | |
Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (AU) | |
| FAPESP's process: | 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters |
| Grantee: | Eder Carlos Rocha Quintão |
| Support Opportunities: | Research Projects - Thematic Grants |