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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats

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Autor(es):
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Andrade, Fabia de Oliveira [1] ; Fontelles, Camile Castilho [1] ; Rosim, Mariana Papaleo [1] ; de Oliveira, Tiago Franco [1] ; de Melo Loureiro, Ana Paula [1] ; Mancini-Filho, Jorge [1] ; Rogero, Marcelo Macedo [2] ; Moreno, Fernando Salvador [1, 3] ; de Assis, Sonia [4] ; Barbisan, Luiz Fernando [5] ; Hilakivi-Clarke, Leena [4] ; Ong, Thomas Prates [1, 3]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, BR-05508900 Sao Paulo - Brazil
[3] Food & Nutr Res Ctr NAPAN, Sao Paulo - Brazil
[4] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC - USA
[5] State Univ Sao Paulo, Botucatu, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 25, n. 6, p. 613-622, JUN 2014.
Citações Web of Science: 25
Resumo

The present study investigated whether early life exposure to high levels of animal fat increases breast cancer risk in adulthood in rats. Dams consumed a lard-based high-fat (HF) diet (60% fat-derived energy) or an AIN93G control diet (16% fat-derived energy) during gestation or gestation and lactation. Their 7-week-old female offspring were exposed to 7,12-dimethyl-benzo{[}a]anthracene to induce mammary tumors. Pregnant dams consuming an HF diet had higher circulating leptin levels than pregnant control dams. However, compared to the control offspring, significantly lower susceptibility to mammary cancer development was observed in the offspring of dams fed an HF diet during pregnancy (lower tumor incidence, multiplicity and weight), or pregnancy and lactation (lower tumor multiplicity only). Mammary epithelial elongation, cell proliferation (Ki67) and expression of NF kappa B p65 were significantly lower and p21 expression and global H3K9me3 levels were higher in the mammary glands of rats exposed to an HF lard diet in utero. They also tended to have lower Rank/Rankl ratios (P=.09) and serum progesterone levels (P=.07) than control offspring. In the mammary glands of offspring of dams consuming an HF diet during both pregnancy and lactation, the number of terminal end buds, epithelial elongation and the BCL-2/BAX ratio were significantly lower and serum leptin levels were higher than in the controls. Our data confirm that the breast cancer risk of offspring can be programmed by maternal dietary intake. However, contrary to our expectation, exposure to high levels of lard during early life decreased later susceptibility to breast cancer. (C) 2014 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 10/11742-0 - Nutrição e origem fetal do câncer de mama: consumo de ração rica em gordura saturada por ratas durante a gestação e suscetibilidade da prole feminina à carcinogênese mamária
Beneficiário:Fábia de Oliveira Andrade
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/23259-4 - Nutrição materna e programação fetal do câncer de mama: importância da interação nutriente-epigenoma nas fases iniciais da vida
Beneficiário:Thomas Prates Ong
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/03330-9 - Análise da morfologia e expressão gênica global de tecido mamário de ratas tratadas in útero com ração rica em ácidos graxos saturados
Beneficiário:Fábia de Oliveira Andrade
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado