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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon

Texto completo
Autor(es):
Munari, Carla C. [1] ; Furtado, Ricardo A. [1] ; Santiago, Mirian L. [1] ; Manhas, Simony S. [1] ; Bastos, Jairo K. [2] ; Tavares, Denise C. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Franca, Franca - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: European Journal of Cancer Prevention; v. 23, n. 4, p. 240-245, JUL 2014.
Citações Web of Science: 1
Resumo

Baccharis dracunculifolia (Asteraceae), the main botanical source of green propolis, also known as `alecrim-do-campo' and `vassourinha', is a shrub of the Brazilian ` cerrado' and is native to the South and Southeast of Brazil. The effects of B. dracunculifolia ethyl acetate extract (Bd-EAE) were evaluated on the 1,2-dimethylhydrazine (DMH)-induced DNA damage and aberrant crypt foci (ACF) in the colon of male Wistar rats by the comet and ACF assays, respectively. The animals were treated by gavage with doses of 6, 12, and 24 mg/kg body weight/day. Animals were also administered a single subcutaneous injection of 40 mg/kg DMH and were killed after 4 h for evaluation of DNA damage. Also, two doses of 40 mg/kg of DMH were administered weekly for 2 weeks, and animals were killed 2 weeks after the last injection for evaluation of ACF development in the colon. The results showed a significant reduction in the frequency of DNA damage and ACF in the group treated with the Bd-EAE plus DMH in comparison with those treated with DMH alone, suggesting that Bd-EAE reduced DNA damage and suppressed the formation of ACF and also exerted a protective affect against colon carcinogenesis. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

Processo FAPESP: 07/00825-9 - Estudo da influencia do extrato de baccharis dracunculifolia sobre os focos de criptas aberrantes induzidos por 1,2 dimetilhidrazina em colon de ratos.
Beneficiário:Mírian Lemos Santiago
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 07/06061-0 - Estudo do potencial antigenotóxico da baccharis dracunculifolia em células v79 e ratos wistar pelo teste do cometa e antimutagênico usando o teste de ames
Beneficiário:Carla Carolina Munari
Modalidade de apoio: Bolsas no Brasil - Mestrado