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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon

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Author(s):
Munari, Carla C. [1] ; Furtado, Ricardo A. [1] ; Santiago, Mirian L. [1] ; Manhas, Simony S. [1] ; Bastos, Jairo K. [2] ; Tavares, Denise C. [1]
Total Authors: 6
Affiliation:
[1] Univ Franca, Franca - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Journal article
Source: European Journal of Cancer Prevention; v. 23, n. 4, p. 240-245, JUL 2014.
Web of Science Citations: 1
Abstract

Baccharis dracunculifolia (Asteraceae), the main botanical source of green propolis, also known as `alecrim-do-campo' and `vassourinha', is a shrub of the Brazilian ` cerrado' and is native to the South and Southeast of Brazil. The effects of B. dracunculifolia ethyl acetate extract (Bd-EAE) were evaluated on the 1,2-dimethylhydrazine (DMH)-induced DNA damage and aberrant crypt foci (ACF) in the colon of male Wistar rats by the comet and ACF assays, respectively. The animals were treated by gavage with doses of 6, 12, and 24 mg/kg body weight/day. Animals were also administered a single subcutaneous injection of 40 mg/kg DMH and were killed after 4 h for evaluation of DNA damage. Also, two doses of 40 mg/kg of DMH were administered weekly for 2 weeks, and animals were killed 2 weeks after the last injection for evaluation of ACF development in the colon. The results showed a significant reduction in the frequency of DNA damage and ACF in the group treated with the Bd-EAE plus DMH in comparison with those treated with DMH alone, suggesting that Bd-EAE reduced DNA damage and suppressed the formation of ACF and also exerted a protective affect against colon carcinogenesis. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

FAPESP's process: 07/06061-0 - Antigenotoxic potential study of Baccharis dracunculifolia in V79 cells and Wistar rats using Comet assay and antimutagenic using Ames assay
Grantee:Carla Carolina Munari
Support Opportunities: Scholarships in Brazil - Master