| Texto completo | |
| Autor(es): |
Lisboa, S. F.
[1]
;
Camargo, L. H. A.
[2]
;
Magesto, A. C.
[2]
;
Resstel, L. B. M.
[2]
;
Guimaraes, F. S.
[2]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; v. 17, n. 8, p. 1193-1206, AUG 2014. |
| Citações Web of Science: | 8 |
| Resumo | |
The present study investigated the effects of systemic or intra-dorsolateral periaqueductal gray (dlPAG) administration of CB1 agonists on behavioural changes induced in rats by predator (a live cat) exposure, a model of panic responses. Since nitric oxide (NO) and cannabinoid neurotransmission are proposed to interact in the dlPAG to modulate defensive responses, we also investigated if NO is involved in the biphasic effects of anandamide (AEA) injected into the dlPAG. The results showed that systemic administration of WIN55,212-2 or intra-dlPAG AEA attenuated the defensive behaviours caused by cat exposure. Both compounds produced biphasic curves. The cannabinoid receptor type 1 (CB1) antagonist AM251 prevented the panicolytic effect of AEA whereas a neuronal NOS inhibitor turned the ineffective high dose of AEA into an effective one. These results suggest that modulation of the cannabinoid system could be a target in the treatment of panic disorders. However, the biphasic effects of these compounds could limit their therapeutic potential. (AU) | |
| Processo FAPESP: | 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos |
| Beneficiário: | Francisco Silveira Guimaraes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 07/06999-9 - Estudo da possível interação entre os sistemas canabinóide e nitrérgico na substância cinzenta periaquedutal dorsolateral na modulação de comportamentos defensivos em ratos |
| Beneficiário: | Sabrina Francesca de Souza Lisboa |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |