| Full text | |
| Author(s): |
Lisboa, S. F.
[1]
;
Camargo, L. H. A.
[2]
;
Magesto, A. C.
[2]
;
Resstel, L. B. M.
[2]
;
Guimaraes, F. S.
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05508 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; v. 17, n. 8, p. 1193-1206, AUG 2014. |
| Web of Science Citations: | 8 |
| Abstract | |
The present study investigated the effects of systemic or intra-dorsolateral periaqueductal gray (dlPAG) administration of CB1 agonists on behavioural changes induced in rats by predator (a live cat) exposure, a model of panic responses. Since nitric oxide (NO) and cannabinoid neurotransmission are proposed to interact in the dlPAG to modulate defensive responses, we also investigated if NO is involved in the biphasic effects of anandamide (AEA) injected into the dlPAG. The results showed that systemic administration of WIN55,212-2 or intra-dlPAG AEA attenuated the defensive behaviours caused by cat exposure. Both compounds produced biphasic curves. The cannabinoid receptor type 1 (CB1) antagonist AM251 prevented the panicolytic effect of AEA whereas a neuronal NOS inhibitor turned the ineffective high dose of AEA into an effective one. These results suggest that modulation of the cannabinoid system could be a target in the treatment of panic disorders. However, the biphasic effects of these compounds could limit their therapeutic potential. (AU) | |
| FAPESP's process: | 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders |
| Grantee: | Francisco Silveira Guimaraes |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 07/06999-9 - Study of possible interaction between cannabinoid and nitrergic systems in the dorsolateral periaqueductal gray on modulation of defensive behaviors in rats |
| Grantee: | Sabrina Francesca de Souza Lisboa |
| Support Opportunities: | Scholarships in Brazil - Doctorate |