Cooperation in science and technology has been developed through joint research projects with the Instituto Jô Clemente (former APAE São Paulo), in the area of Intellectual Disabilities, especially in the following lines of research: Genetics and Molecular Biology; Cognition and Development; Brain Imaging; Neonatology and Neonatal Screening; Aging; and Inclusive Education, aiming to expand knowledge on Intellectual Disabilities in Brazil.
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction, communication, and behavior, as well as sensory processing deficits (DSM-5-TR). Among the symptoms of ASD, the high prevalence of sleep disorders stands out, with negative consequences for behavioral changes, mood instability, sensory processing, and neurocognitive …
This study aims to characterize motor skills and brain connectivity in children with ASD using functional magnetic resonance imaging (fMRI). The research addresses a critical need to understand the comorbidities in motor performance often observed in ASD, which can compromise short- and long-term cognitive and social gains. The results may contribute to the personalization of rehabilitati…
Sleep is a regulatory factor for homeostasis, behavior, and emotions. Therefore, sleep disorders can compromise several physiological functions. In individuals with syndromic autism spectrum disorder (ASD), there is a wide variety of implicated genomic alterations. However, the underlying genetic mechanisms of sleep disorders are not clear. This study aims to investigate, identify, and ch…
(Only some records are available in English at this moment)
Down Syndrome (DS) or trisomy 21 is the most common genetic cause of mild to moderate intellectual disability in the world. The life expectancy of DS patients has increased in the last decades and, therefore, the incidence of dementia, especially Alzheimer's Disease (AD) increases in this population, making aging a new and important area of study in DS. Molecular neuroimaging allows in vi…
Down syndrome (DS), which is the consequence of the trisomy of chromosome 21 (T21), has an approximate incidence of 1:660 live births. DS is the most prevalent cause of intellectual disability of genetic origin and results in general cognitive impairment, which is typically in the mild-to-moderate range. Although DS has been known for over 160 years, our knowledge regarding the mechanisms…
The increase of life expectancy of the general population, with or without disabilities, brings comfort and new perspectives for people and their families. However, also creates concerns about the quality of life of those who .have some limitation in their autonomy. This way, it is fundamental to invest in research aimed at improving the quality of life and the promotion of independence i…
Evidence indicates that children with trisomy 21 (T21) exhibit low levels of physical activity. Recommendations to combat inactivity emphasize engaging in physical activities from the first months of life. According to the World Health Organization, children under 1 year of age should accumulate at least 30 minutes of tummy time (TT) per day. However, no studies to date have examined TT t…
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
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