Abstract
We hypothesize that the constitutive expression of one or more NADPH oxidase components and the function of the entire NADPH oxidase complex is dependent on IFN-gamma in human mocrophages and probably in dendritic cells. Thus, inborn errors of IFN-gamma responses in patients with Mendelian Susceptibility to Mycobacterial Infections (MSMD) with IFNGR deficiency should result in defective e…
