Influence of argon plasma on incorporation of HA / TCP graft. Histomorphometric and microtomographic study on rabbits maxillary sinuses.

• Grant number: 18/14303-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Samuel Porfirio Xavier
• Grantee: Samuel Porfirio Xavier
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 19/15569-5 - Influence of argon plasma on the incorporation of ha / beta TCP graft: morphometric study in maxillary sinuses of rabbits, BP.TT

Abstract

Twenty male New Zealand rabbits (3.5-4.0 kg) will be used to raise the maxillary sinus and divided into 2 groups composed of 10 animals each, according to the experimental times: 2 and 10 weeks. After bilateral sinus membrane elevation, a similar amount (50 mg) of HA / bTCP (60% hydroxyapatite, 40% beta-tricalcium phosphate, GUIDOR calc-oss CRYSTAL +, Sunstar, Etoy, Switzerland), with granulation of 450 - 1000 micrometers will be introduced into the raised spaces. According to the randomization, on the test side, the grafting material will be previously submitted to a treatment with plasma reactor (10W, 1 bar for 12 min, Plasma R, Sweden and Martina). On the control side, the grafting material will not be treated. The animals will be euthanized according to the experimental times proposed. The specimens removed will be forwarded for microtomographic and histological processing, so that it is possible to investigate the influence of argon plasma on the HA / bTCP graft in terms of bone incorporation and remodeling. (AU)