Translational medicine: hepatocellular regeneration, hemodynamics and portal modulation study in a clinical and experimental model of Small-for-size Syndrome

• Grant number: 19/14321-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2019
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Lucas Souto Nacif
• Grantee: Lucas Souto Nacif
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Flávio Henrique Ferreira Galvão ; Luiz Augusto Carneiro D'Albuquerque ; Wellington Andraus
• Associated scholarship(s): 21/04262-6 - Translational medicine: hepatocellular regeneration, hemodynamics and portal modulation study in a clinical and experimental model of Small-for-Size Syndrome, BP.TT

Abstract

The appropriate hepatocellular regeneration is needed for successful hepatectomy or liver transplant partially graft with these excessive regeneration hepatocytes in the absence of a parallel growth of non-parenchymal cells leads to changes in the micro-architecture of the tissue that they are critical in the pathogenesis of the syndrome SFS. In a pre-clinical model clinically relevant to be able to identify the critical factors involved in the pathological regeneration, and may also serve as potential therapeutic targets for prevention of hepatocellular excessive growth. Considering these points, we aim through surgical or pharmaceutical intervention to demonstrate a significant improvement in tissue microarchitecture, function, and outcome after major liver resection or transplantation with partial liver grafts. (AU)