Immunogenetic markers of clincial evolution of COVID-19

• Grant number: 20/06471-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2021
• End date: September 30, 2024
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Luiz Carlos de Mattos
• Grantee: Luiz Carlos de Mattos
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Associated researchers: Cinara de Cássia Brandão ; Maurício Lacerda Nogueira

Abstract

Infection with the new coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2) and the clinical course of the resulting disease (Coronavirus Disease: COVID-19) are significant challenges for contemporary science, as they represent a severe public health problem. The majority of individuals infected with SARS-CoV-2 remain asymptomatic, while approximately one fifth has a clinical evolution of heterogeneous COVID-19, ranging from mild to severe cases, whether or not followed by death. In this context, the investigation of immunogenetic markers in infected individuals (symptomatic [mild and severe] and asymptomatic) favours the immunogenic understanding of humans in the face of SARS-CoV-2 infection and clinical evolution of COVID-19. (AU)