Micro- and nanotopography-based stem cell priming technology for cell therapy

• Grant number: 22/03820-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2022
• End date: July 31, 2024
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Agreement: Monash University
• Principal Investigator: Adalberto Luiz Rosa
• Grantee: Adalberto Luiz Rosa
• Principal researcher abroad: Peter Ebeling
• Institution abroad: Monash University, Australia
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Jessica Frith ; Márcio Mateus Beloti
• Associated research grant: 17/12622-7 - Cell therapy: potential of mesenchymal stem cells, VEGF-A and BMP-9 to regenerate bone tissue, AP.TEM

Abstract

Bone exhibits high healing potential but depending on the damage extension additional treatments are needed to assure tissue repair. Therapies based on cells produce meaningful bone formation; however, without inducing the complete bone regeneration. Based on evidences that modifications of cells enhance their capacity to regenerate tissues, the aim of this project is to regenerate bone using modified stem cells generated by growing them on unique surface topographies and injecting these cells on rat skull defects. The innovation of this study is the use of topographies instead of drugs or genetic modifications to control cell functions, facilitating the clinical applications. (AU)