Cellular and molecular aspects of acute renal insufficiency

• Grant number: 97/01015-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 1997
• End date: August 31, 2002
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Nestor Schor
• Grantee: Nestor Schor
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant(s): 98/10429-2 - 1) Mechanisms of altered intracellular calcium in cultured vascular smooth muscle cells, AR.EXT

Abstract

This project is aimed at the analysis of various intercellular mechanisms involved in the processes of installation, maintenance and recuperation from severe renal insufficiency (SRI). Among these processes which lead to imbalance in the cell functions we intend to evaluate the intercellular alterations in pH and Ca+2, production of hormones, mitogenic vessel-active substances, enzymes, hydroelectrolytic alterations through study of transporters, pumps and ionic canals, as well as immunological aspects. For this type of analyses various models of SRI will be used, including ischemia, toxicity and post-transplant SRI, combining with modern techniques in cell biology, already incorporated in this procedure. (AU)