Evaluation of ventricular-arterial coupling and ventricular efficiency in chronic thromboembolic pulmonary hypertension

• Grant number: 22/12143-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2023
• End date: January 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rogério de Souza
• Grantee: Rogério de Souza
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Bruna Mamprim Piloto

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the forms of pulmonary hypertension with most therapeutic possibilities. Characterized by chronic obstruction of vascular lumen, as a late complication of an acute pulmonary embolism, CTEPH has the surgical removal of chronic thrombi as the treatment of choice, with potential to cure pulmonary hypertension. In addition to the surgical procedure, pulmonary angioplasty and medical treatment are alternatives with great potential for improving functional capacity. However, the pivotal aspect of pulmonary vascular disease is the ventricular response to the load imposed by downstream vascular changes. Ventricular remodeling may be influenced by several factors and little is known about the effect of different therapeutic modalities on remodeling, metabolism and mechanics of the right ventricle. This project aims to understand the behavior of right ventricular mechanics and its energetic metabolism in CTEPH, with the perspective that its evaluation may become a robust criterion for choosing the best therapeutic modality to be used. (AU)