Investigation of mesoporous nanoparticles from bioactive glasses containing niobium in bone tissue engineering

• Grant number: 22/03247-6
• Support Opportunities: Research Grants - Initial Project
• Start date: February 01, 2023
• End date: January 31, 2028
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: João Henrique Lopes
• Grantee: João Henrique Lopes
• Host Institution: Divisão de Ciências Fundamentais (IEF). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
• Associated researchers: Alviclér Magalhães ; Celso Aparecido Bertran ; Filipe Vargas Ferreira ; Ivone Regina de Oliveira ; Lucas Pereira Lopes de Souza ; Luciane Portas Capelo
• Associated research grant(s): 23/07910-4 - Multi-user Equipment approved in grant 2022/03247-6: Fourier-Transform Infrared Spectroscopy (FTIR), AP.EMU
• Associated scholarship(s): 25/07220-3 - Investigation of the mechanism of ultrasonic phosphate bond formation (LUF)., BP.IC; 25/01038-9 - Development of a bioactive injectable system for controlled ion release with osteostimulatory effects and selective action on tumor cells - osteosarcoma, BP.DR

Abstract

This project proposes to investigate the potential of mesoporous nanoparticles of bioactive glasses containing niobium (MBGNb) as bioactivity promoting agents in bone tissue engineering. The strategy is to combine and explore the advantages of systems in nanometric dimensions and the intrinsic ability of bioactive glasses in the controlled delivery of biologically important species that stimulate/accelerate the biomineralization processes related to bone regeneration. The motivation arises from the urgent demand for more effective alternatives in the management of bone injuries caused by both trauma and disease. To assess the potential of MBGNb, a set of robust studies organized into four research plans was proposed: i) Assembly and characterization of vitreous scaffolds; ii) Multifunctional bioactive injectable paste; iii) Bilayer hybrid barrier membranes for guided bone regeneration; iv) Hybrid bioinks for bioprinting functional constructs for bone tissue engineering. In all these studies, we aim to explore the applications of MBGNb nanoparticles in tissue engineering and try to answer prominent questions related to the effectiveness of these glassy nanoparticles in ion therapy and biomineralization. The proposal is set to answer pressing questions across disciplines and is strongly tied to bioengineering research, with special attention to bone tissue engineering. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, FILIPE V.; SOUZA, ALANA G.; AJDARY, RUBINA; DE SOUZA, LUCAS P.; LOPES, JOAO H.; CORREA, DANIEL S.; SIQUEIRA, GILBERTO; BARUD, HERNANE S.; ROSA, DERVAL DOS S.; MATTOSO, LUIZ H. C.; et al. Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine. BIOACTIVE MATERIALS, v. 29, p. 26-pg., 2023-11-01. (18/22214-6, 20/07956-6, 16/10636-8, 22/03247-6)

BERNARDO, M. P.; FERREIRA, F. V.; OLIVEIRA, L. F.; MATTOSO, L. H. C.; LOPES, J. H.. Revolutionizing bone regeneration: 3D printing of PLA/MFBG composites with advanced healing properties. MATERIALS TODAY CHEMISTRY, v. 43, p. 13-pg., 2024-12-20. (23/07910-4, 18/07860-9, 20/07956-6, 22/03247-6)

FERNANDES, PAULA CRISTINA GOMES; FILGUEIRAS, VIVIANE FAJARDO; MATTE, BIBIANA FRANZEN; LOPES, JOAO HENRIQUE. A comprehensive rheological study on the influence of ion charge density and valence in ionotropically crosslinked alginate hydrogels for bioprinting. International Journal of Biological Macromolecules, v. 316, p. 13-pg., 2025-06-01. (22/03247-6, 22/11767-0, 22/07967-3, 23/07910-4)

GANEM, G. C. A.; OLIVEIRA, L. F. M.; PAGAN, B. M.; OKAMOTO, S.; LOPES, J. H.. Unlocking the potential of multicomponent mesoporous bioactive glass nanoparticles: An approach to enhanced ion therapy. Journal of Non-Crystalline Solids, v. 638, p. 14-pg., 2024-06-11. (22/03247-6, 23/00747-0)

AGUIAR, ANA CAROLINA; BIANCHI, JHONATAN R. O.; LOPES, JOAO HENRIQUE; FERREIRA, FILIPE V.; LONA, LILIANE MARIA FERRARESO. Nanocellulose-Based Capsules with pH Responsiveness for Colon-Targeted Curcumin Delivery. ACS APPLIED NANO MATERIALS, v. 8, n. 4, p. 13-pg., 2025-01-21. (23/12419-8, 22/03247-6, 20/07956-6, 23/07910-4, 21/09341-1, 21/00980-1)

DA ROCHA, GEOVANA VILAS BOAS; LOPESS, JOAO HENRIQUE; TRAVESSA, DILERMANDO NAGLE; JORGE JR, ALBERTO MOREIRA; ROCHE, VIRGINIE. Multifunctional bioactive coating on biomedical β-Ti12Mo6Zr2Fe alloy to improve corrosion protection and bioactivity properties. Applied Surface Science, v. 645, p. 13-pg., 2023-11-15. (22/03247-6)

FERREIRA, FILIPE V.; EZAZI, NAZANIN Z.; OTONI, CAIO G.; AGUIAR, ANA CAROLINA; BIANCHI, JHONATAN R. O.; LOPES, JOAO H.; DOS SANTOS, DANILO M.; GRECA, LUIZ G.; BARUD, HERNANE S.; SANTOS, HELDER A.; et al. In Situ Biofabrication of Microbial Cellulose Capsules Carrying Cubosomes: Toward Colon Targeted Multidrug Delivery. ACS APPLIED POLYMER MATERIALS, v. 6, n. 7, p. 13-pg., 2024-04-01. (22/03247-6, 20/07956-6, 17/20973-4, 21/12071-6, 16/10636-8, 21/00980-1, 18/22214-6)