Effect of methotrexate in endothelial function of patients with moderate to severe Psoriasis

• Grant number: 22/16802-8
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2023
• End date: April 30, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Renata Ferreira Magalhães
• Grantee: Renata Ferreira Magalhães
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Andrei Carvalho Sposito ; Isabella Bonilha de Oliveira ; Simone Appenzeller
• Associated scholarship(s): 23/05845-0 - Effect of methotrexate in endothelial function of patients with moderate to severe psoriasis, BP.TT

Abstract

Psoriasis is a systemic, chronic and immune-mediated inflammatory disease that affects 2-3% of the world's population. In psoriatic patients, a higher prevalence of cardiovascular risk factors has been described, such as diabetes mellitus, obesity, smoking, dyslipidemia and metabolic syndrome. The present study aims to evaluate the alteration of endothelial function in patients with moderate to severe psoriasis in order tounderstand the pathophysiology of the disease, since atherosclerosis shares common pathophysiological mechanisms. For this purpose, 45 people with moderate to severe psoriasis and 45 healthy people will be selected to compose the control group. All will under go laboratory tests and examination of endothelial function by means of flow mediated vasodilation (Flow Mediated Dilation - FMD). Psoriatic patients will under go treatment with Methotrexate. At the end of the study, it is expected to obtain a greater understanding of moderate to severe psoriasis, as well as an improvement in endothelial function with the use of Methotrexate. (AU)