Carboprata(R): an active ingredient for dermocosmetics development

• Grant number: 22/13713-4
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: June 01, 2023
• End date: May 31, 2024
• Field of knowledge: Biological Sciences - Biophysics
• Agreement: SEBRAE-SP
• Principal Investigator: Selma Isabel Rodrigues
• Grantee: Selma Isabel Rodrigues
• Company: ADP Água de Prata Tecnologia em Soluções Metálicas Ltda
• CNAE: Fabricação de produtos químicos inorgânicos não especificados anteriormente ; Fabricação de produtos de limpeza e polimento ; Fabricação de máquinas e equipamentos para uso industrial específico não especificados anteriormente
• City: São Paulo
• Associated researchers: Lígia Ferreira Gomes ; Marianna Gabriela Almasy
• Associated scholarship(s): 23/05162-0 - Carboprata(R): an active ingredient for dermocosmetics development, BP.TT

Abstract

The current proposal is about the technological validation of a solution developed by ADP Soluções, named carboprata®, which is the result of FAPESP's PIPE Stage 2 Direct / 3rd Cycle (2016), numbered 2016/15413-7; and the PIPE Stage 3 / 9th Cycle (2021) numbered 2022/01699-7, currently in progress. AERCAMP is the partner company of ADP SOLUÇÕES, which is interested in developing a new dermo cosmetic product, specifically a Thermal Water, and plans to commercialize it under its own brand. The current proposal aims to validate carboprata® as one of the main active ingredients of the new product's formulation. In addition to the various tests that carboprata® must undergo to prove its safety and efficacy as one of the dermo cosmetic raw materials, we have included in the scope of the proposal, a marketing follow-up for the creation and development of the carboprata® brand, since ADP's business model and growth strategy is being designed with the carboprata® brand as its core element, complementing the work already in progress for PIPE Stage 3 project. To prove carboprata®'s safety as a raw material, microbiological, chemical contaminant, preservative efficacy, and stability tests have been planned. And regarding its effectiveness, dermatological and efficacy tests may be applied, of course, this set of tests varies according to the desired claims for Thermal Water. As the Thermal Water formulation contains a number of different raw materials and active principles, it will be necessary to study how their integration will take place. Tests to obtain the ideal formulation should constitute a good part of the work schedule for this project. Thermal Water is simply a more mineralized version of common water, including on its composition iron, magnesium, potassium, calcium, among others. That's why it can replenish the mineral salts present in the human body, and it also acts to alleviate various problems present in human skin. Among the expected benefits we can list the following, Thermal Water: i) hydrates, tones and refreshes the skin; ii) has antioxidant function; iii) soothes and relieves itching and irritations; iv) alleviates the sensation of burns (after exposure to the sun); v) relieves skin irritation after shaving or waxing; vi) helps to cleanse the skin and set makeup.Silver has been known for its antimicrobial properties since antiquity, long before the discovery of antibiotics (1928) it was already recognized for such properties and used by doctors at that time. There are reports of the adoption of silver by Chinese and Hindu medicine, dating back to 1000 BC. In more years (80's, 90's) its use has been increasingly restricted and its adoption as a biocidal agent has been greatly reduced. A survey carried out with the search engine PubMed, which specializes in citations and abstracts of articles in the field of biomedicine, showed a brutal increase in the number of publications related to silver nanoparticles (AgNP) in the last 3 years (2019 to 2021). In other words, it is a topic that has been drawing the attention of both the scientific community and companies, which have been rediscovering the use of silver, now in the form of nanoparticles, and it is this window of opportunity that ADP SOLUÇÕES intends to use to enter in the market in a more robust and planned way. In the general public's eye, silver still has a negative image, perhaps due to an association with the idea of a heavy metal that accumulates in the human body and present deleterious effects over time. But our conviction is that a more serious and structured communication work has always been lacking, with the objective of showing the real benefits and limitations of the use of this chemical element. Both companies believe in the great potential of carboprata® as a raw material for the development of new products and are grateful for the opportunity to present this proposal. (AU)