Serum levels of microRNA-103a, microRNA-149, iNOS, endothelin-1, IL-6, TNF-alpha and VCAM-1 and their correlations with the severity of the systemic inflammatory response after cardiac operations with cardiopulmonary bypass

• Grant number: 22/09049-1
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2023
• End date: May 31, 2025
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Alfredo José Rodrigues
• Grantee: Alfredo José Rodrigues
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Federico Enrique Garcia Cipriano ; Li Siyuan

Abstract

The application of cardiopulmonary bypass (CPB) in cardiovascular surgery began in the 1950s. Since then, much has been studied about the Systemic Inflammatory Reaction Syndrome (SIRS) associated with CPB. It is known that CPB-associated SIRS has a multifactorial cause, with pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-±), and the vascular endothelium. In addition, there are studies in the literature demonstrating the participation of microRNAs 103a and 149 in SIRS after CPB use and their relationship with inflammatory cytokines. This project proposes verifying the serum levels of these two microRNAs, the pro-inflammatory cytokines, and their correlation with the clinical severity of SIRS after CPB. (AU)