Relationship between metabolism and innate immune response cells function before and after exercise in people with different levels of physical fitness

• Grant number: 21/09047-6
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2023
• End date: June 30, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Ronaldo Vagner Thomatieli dos Santos
• Grantee: Ronaldo Vagner Thomatieli dos Santos
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Elias de França ; Geovana Silva Fogaça Leite

Abstract

Physical exercise can modify the function of immune cells such as monocytes. These changes may be due to the intensity and volume of the exercise and the outcome is the less probability of trained people becoming ill and faster recovery in case of illness, especially inflammatory and chronic diseases. The mechanisms that permeate the effects of exercise on monocytes are not yet fully understood and include endocrine and immunometabolic changes. With proteomics and metabolomics in this study, amplified and in-depth investigation will be possible, focused on the potential that physical exercise has to influence the synthesis of different proteins, modify the activation of different biochemical pathways, modify the availability of substrates and generate metabolites in monocytes, which thus modify the functionality of the cells. For this, people with different levels of training will be subjected to two exercise sessions with different intensities. Monocytes will be collected before and after the exercises to assess function, and metabolomics. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAVARES-SILVA, EDGAR; LEMOS, VALDIR DE AQUINO; DE FRANCA, ELIAS; SILVESTRE, JEAN; DOS SANTOS, SAMILE AMORIM; RAVACCI, GRAZIELA ROSA; THOMATIELI-SANTOS, RONALDO VAGNER. Protective Effects of Probiotics on Runners' Mood: Immunometabolic Mechanisms Post-Exercise. NUTRIENTS, v. 16, n. 21, p. 11-pg., 2024-11-01. (21/12660-1, 21/09047-6)

MARQUES, CAMILA GUAZZELLI; QUARESMA, MARCUS V. L. DOS SANTOS; FERRACINI, CATARINA BORTOLOTO FRANCA; CARRILHO, FILIPA BETTENCOURT ALVES; NAKAMOTO, FERNANDA PATTI; LUCIN, GLAICE APARECIDA; MAGALHA, ANA CAROLINA OUMATU; MENDES, GABRIELA LIMA; ALVARES, LEONARDO AZEVEDO; THOMATIELI-SANTOS, RONALDO VAGNER. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clinical Nutrition, v. 45, p. 16-pg., 2025-01-21. (23/18422-0, 19/22524-8, 21/09047-6)