Impact of a preventive strategy based on the risk stratification on the outcome of liver transplant recipients colonized with carbapenem resistant Enterobacterales: a pre-post quasi experimental study

• Grant number: 22/10632-3
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2023
• End date: July 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Maristela Pinheiro Freire
• Grantee: Maristela Pinheiro Freire
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alice Tung Wan Song ; Anna Sara Shafferman Levin ; Carlos Henrique Camargo ; Edson Abdala ; Elisa Donalisio Teixeira Mendes
• Associated scholarship(s): 23/16163-8 - The impact of a preemptive strategy based on risk stratification on the infection by carbapenem-resistant Enterobacterales among liver transplant recipients colonized by CRE: a quasi-experimental study, BP.TT; 23/12118-8 - Risk factors for carbapenem-resistant Enterobacterales among liver transplant recipients, BP.TT

Abstract

The aim of this study is to assess the impact of a prevention strategy based on the use of a previously derived and validated risk stratification tool (CRECOOLT score) on all-cause 90-day mortality, in all consecutive adult patients undergoing orthotopic liver transplantation (OLT) and found to be colonized with carbapenem-resistant Enterobacterales (CRE) before or after transplantation, by a multicentre pre and post quasi-experimental study. Secondary outcomes will include days of therapy with old and new anti-CRE antibiotic regimens, rates of documented CRE infections and their relapses with selection of further resistance, lengths of hospital and ICU stays and hospital readmission. (AU)